Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Bioorganic & medicinal chemistry letters (2007-09-22)

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

ABSTRAKT

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

MATERIAŁY

Numer produktu

Marka

Opis produktu

Sigma-Aldrich

5-Bromo-2,4-dichloropyrimidine, 97%