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Merck

Synthesis and antiproliferative activity of novel α-aminophosphonates.

Chemical & pharmaceutical bulletin (2012-09-19)
Anil Kumar Mungara, Yong-Ki Park, Kap Duk Lee
ABSTRAKT

A novel series of carbazole-based α-aminophosphonates were synthesized by three component coupling of 6-bromo-9-ethyl-9H-carbazole-3-carbaldehyde, amine and diethyl phosphite using polyethylene glycol (PEG-400) as a green reaction media. The antiproliferative activity of these molecules was evaluated against three cancer cell lines. Of these, compounds 4c, 4e and 4m were found to exhibit good antiproliferative activity against three cancer cells, A549, MCF-7, and NCI-N87.

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Sigma-Aldrich
Diethyl phosphite, technical grade, 94%