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Merck

Sulbactam-containing beta-lactamase inhibitor combinations.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (2007-12-25)
M Akova
ABSTRAKT

Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum beta-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce class I (Ampc) chromosomal beta-lactamases in Enterobacteriaceae.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Sulbactam
Sulbactam, European Pharmacopoeia (EP) Reference Standard
Sulbactam for peak identification, European Pharmacopoeia (EP) Reference Standard