- N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols.
N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols.
The Journal of organic chemistry (2003-12-06)
Joseph Bejjani, Fabrice Chemla, Max Audouin
PMID14656102
ABSTRAKT
N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.
MATERIAŁY