- Enantioselective intramolecular C-H insertion reactions of donor-donor metal carbenoids.
Enantioselective intramolecular C-H insertion reactions of donor-donor metal carbenoids.
Journal of the American Chemical Society (2014-10-14)
Cristian Soldi, Kellan N Lamb, Richard A Squitieri, Marcos González-López, Michael J Di Maso, Jared T Shaw
PMID25308822
ABSTRAKT
The first asymmetric insertion reactions of donor-donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary results show similar efficiency in the preparation of indanes. This new method is used in the first enantioselective synthesis of an oligoresveratrol natural product (E-δ-viniferin).