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Merck

Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.

Cell cycle (Georgetown, Tex.) (2017-06-27)
David Frescas, Brandon M Hall, Evguenia Strom, Lauren P Virtuoso, Mahima Gupta, Anatoli S Gleiberman, Elena Rydkina, Vitaly Balan, Slavoljub Vujcic, Olga B Chernova, Andrei V Gudkov
ABSTRAKT

Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies.

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Anti-HMGB1 (HMG1) (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution