WH0001421M3
Monoclonal Anti-CRYGD antibody produced in mouse
clone 4E12, purified immunoglobulin, buffered aqueous solution
Synonim(y):
Anti-CACA, Anti-CCA3, Anti-CRYG4, Anti-crygD, Anti-crystallin, gamma D
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
białko sprzężone:
unconjugated
application:
ELISA (i)
WB
WB
klon:
4E12, monoclonal
reaktywność gatunkowa:
mouse
citations:
1
metody:
indirect ELISA: suitable
western blot: 1-5 μg/mL
western blot: 1-5 μg/mL
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
4E12, monoclonal
Formularz
buffered aqueous solution
reaktywność gatunkowa
mouse
metody
indirect ELISA: suitable
western blot: 1-5 μg/mL
izotyp
IgG1κ
numer dostępu GenBank
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CRYGD(1421)
Opis ogólny
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. (provided by RefSeq)
Immunogen
CRYGD (NP_008822, 75 a.a. ~ 174 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
Sequence
SVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
Postać fizyczna
Solution in phosphate buffered saline, pH 7.4
Informacje prawne
GenBank is a registered trademark of United States Department of Health and Human Services
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Kod klasy składowania
10 - Combustible liquids
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Haruki Hasegawa
Experimental cell research, 379(1), 92-109 (2019-03-10)
Intracellular protein crystallization occurs under various physiological and pathological settings, yet the underlying cellular processes remain enigmatic. After validating individual crystallization events using cellular proteins that readily crystallize in the ER (NEU1), cytosol (crystallin-γD mutant) or nucleus (CLC protein), I
Qiong Hong et al.
Rheumatology (Oxford, England), 53(11), 1994-2001 (2014-06-08)
The aim of this study was to describe the associations between serum levels of 25-hydroxyvitamin D [25(OH)D] and disease activity, inflammatory cytokines and bone loss/erosions in patients with RA. The study included 130 patients with RA and 80 healthy controls.
Hand ultrasound: comparative study between "no rhupus" lupus erythematosus and rheumatoid arthritis.
Ana Letícia Pirozzi Buosi et al.
Modern rheumatology, 24(4), 599-605 (2014-01-01)
To compare hand US between systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. Hands (1st-5th metacarpophalangeal [MCP] and 1st-5th proximal interphalangeal [PIP] joints) and wrists (radiocarpal and distal radioulnar joints) of 62 "no rhupus" SLE and 60 RA patients
Shengqian Xu et al.
Clinical and experimental rheumatology, 32(5), 697-704 (2014-07-30)
This paper aims to investigate the influence of single-nucleotide polymorphisms (SNPs) in the receptor of activator of nuclear factor kappaB ligand (RANKL) gene (TNFSF11) and osteoprotegerin (OPG) gene (TNFRSF11B) on bone and joint injury in patients with rheumatoid arthritis (RA).
Jeremy Sokolove et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(4), 813-821 (2014-04-24)
The co-occurrence of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity in rheumatoid arthritis (RA) is well described. However, the mechanisms underlying the potential interaction between these 2 distinct autoantibodies have not been well defined. The aim of this
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