V2753

Virginiamycin M₁

≥95% (HPLC)

• Synonim(y): Ostreogrycyna A, Prystynamycyna IIA, Staphylomycin M1, Streptogramina A, Virginiamycyna M1
• Wzór empiryczny (zapis Hilla): C₂₈H₃₅N₃O₇
• Numer CAS: 21411-53-0
• Masa cząsteczkowa: 525.59
• Numer WE: 244-376-6
• Numer MDL: MFCD00869411
• Kod UNSPSC: 51283805
• Identyfikator substancji w PubChem: 24900736
• NACRES: NA.85

Właściwości

• pochodzenie biologiczne: Streptomyces virginiae
• Poziom jakości: 200
• Próba: ≥95% (HPLC)
• Formularz: powder
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place.)
• kolor: white to yellow
• rozpuszczalność: methanol: soluble 10 mg/mL
• spektrum działania antybiotyku: Gram-positive bacteria
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c3coc(CC(=O)C[C@H](O)C=C(C)C=CCNC(=O)C=C[C@H]1C)n3
• InChI: 1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5-,10-9-,18-13-/t19-,20-,26-/m1/s1
• Klucz InChI: DAIKHDNSXMZDCU-QHKJSJJMSA-N

Opis

Opis ogólny

Chemical structure: macrolide

Zastosowanie

The antibiotic virginiamycin is produced by Streptomyces virginiae and is a member of the virginiamycin family. Each member is produced as a mixture of two structurally different compounds that exhibit synergistic antibacterial activity. There are two groups: virginiamycin M1 (VM1) and virginiamycin S (VS). VM1 is a polyunsaturated macrocyclic petolide. VM1 and VS are both used to inhibit protein synthesis since they are bacteriostatic. When used in combination they are more effective. Virginiamycin is used as a performance promoter in animal husbandry. They are chemically modified to make therapeutic drugs such as quinupristin and dalfopristin.

Działania biochem./fizjol.

Virginiamycin M1 inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. S. virginiae inactivates VM1 by reducing its 16-carbonyl group, forming 16R-dihydroVM1. VM1 reductase participates solely in VM1 inactivation in vivo.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)