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T3450
Thiolutin
from Streptomyces luteosporeus, ≥95% (HPLC)
Synonim(y):
Farcinicin, N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl), Propiopyvothine
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About This Item
Wzór empiryczny (zapis Hilla):
C8H8N2O2S2
Numer CAS:
Masa cząsteczkowa:
228.29
Numer MDL:
Kod UNSPSC:
12352105
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
pochodzenie biologiczne
Streptomyces luteosporeus
Poziom jakości
Próba
≥95% (HPLC)
Formularz
solid
rozpuszczalność
DMSO: 0.90 - 1.10 mg/ml, clear, yellow
spektrum działania antybiotyku
fungi
Tryb działania
enzyme | inhibits
Warunki transportu
wet ice
temp. przechowywania
−20°C
ciąg SMILES
CCC(=O)NC1=C2SSC=C2N(C)C1=O
InChI
1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
Klucz InChI
UGZYFXMSMFMTSM-UHFFFAOYSA-N
Zastosowanie
Thiolutin has been used as a polymerase II inhibitor:
- to study its effects on yeast cells to calculate transcript half-life
- to study its effects on transcription during germination in budding yeast
- to study its effects on cell adhesion in zebrafish
Działania biochem./fizjol.
Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
Uwaga dotycząca przygotowania
Thiolutin dissolves in DMSO at 0.90 - 1.10 mg/ml to yield a clear, yellow solution.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 2 Oral
Kod klasy składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
A Joshi et al.
Antimicrobial agents and chemotherapy, 22(4), 541-547 (1982-10-01)
Spontaneous mutants of Salmonella typhimurium isolated in our laboratory from thiolutin-containing tryptone agar plates are partially resistant to thiolutin in enriched media. In minimal media, they are not resistant. The mutants are not temperature sensitive but fail to support the
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
A O'Neill et al.
Antimicrobial agents and chemotherapy, 44(11), 3163-3166 (2000-10-19)
A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin
K Minamiguchi et al.
International journal of cancer, 93(3), 307-316 (2001-07-04)
Recent studies have shown that integrin alpha v beta 3, a receptor for vitronectin, plays an important role in tumor-induced angiogenesis and tumor growth and that antagonists of alpha v beta 3 inhibit angiogenic processes including endothelial cell adhesion and
J Abrahão-Neto et al.
Biochemistry, 34(33), 10456-10462 (1995-08-22)
We examined the effects of inhibition of mitochondrial functions on the expression of two nuclear genes encoding the extracellular cellobiohydrolase I (cbh1) and endoglucanase I (egl1) of the cellulase system of the filamentous fungus Trichoderma reesei. The cbh1 and egl1
Jörg Grigull et al.
Molecular and cellular biology, 24(12), 5534-5547 (2004-06-01)
Using DNA microarrays, we compared global transcript stability profiles following chemical inhibition of transcription to rpb1-1 (a temperature-sensitive allele of yeast RNA polymerase II). Among the five inhibitors tested, the effects of thiolutin and 1,10-phenanthroline were most similar to rpb1-1.
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