SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• Synonim(y): ACRP30headless:A-proliferation-inducing ligand, ACRP30headless:APRIL, ACRP30headless:CD256, TNFSF10
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: mouse
• rekombinowane: expressed in HEK 293 cells
• znacznik: FLAG^® tagged
• Próba: >95% (SDS-PAGE)
• Postać: lyophilized
• masa cząsteczkowa: ~34 kDa by SDS-PAGE
• opakowanie: pkg of 10 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• zanieczyszczenia: <0.02 EU/μg endotoxin, tested
• kolor: white
• numer dostępu UniProt: Q9D777
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: mouse ... Tnfsf13(69583)

Opis

Opis ogólny

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

Postać fizyczna

Lyophilized from PBS.

Rekonstytucja

Reconstitute with 100 μL deionized water.

Inne uwagi

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

Informacje prawne

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable