SRP8025
TRAIL, Soluble mouse
recombinant, expressed in E. coli, His tagged, >95% (SDS-PAGE)
Synonim(y):
Apo-2L, CD253, JAG2, TRAIL
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About This Item
pochodzenie biologiczne
mouse
rekombinowane
expressed in E. coli
znacznik
His tagged
Próba
>95% (SDS-PAGE)
Postać
liquid
masa cząsteczkowa
~24 kDa
opakowanie
pkg of 20 μg
stężenie
≥0.2 mg/mL
zanieczyszczenia
<0.01 EU/μg endotoxin, tested
kolor
clear
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
mouse ... Tnfsf10(22035)
Opis ogólny
Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a type II transmembrane protein and belongs to the TNF superfamily of ligands. Trimerisation of TRAIL around a centrally positioned Zn atom is needed for maintaining its stability, solubility and biological activity as a death ligand. TRAIL exists in two forms, soluble and membrane bound.
Działania biochem./fizjol.
Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) activates the extrinsic apoptotic pathway by binding death receptors (DR) 4 and 5. In addition to DR 4 and 5, TRAIL activates several other receptors such as decoy receptor (DcR)1, DcR2 and a soluble receptor called osteoprotegerin. TRAIL plays a vital role in the inhibition of autoimmune inflammation and cell cycle progression. TRAIL selectively kills tumor cells without damaging normal tissues and therefore, it might act as a tumor-selective anticancer agent. TRAIL-induced apoptosis is involved in various cellular processes including activation-induced cell death, homeostasis, intrathymic negative selection, autoimmunity suppression, and immune surveillance. Repeated dosage of recombinant soluble TRAIL triggers apoptosis, inhibits tumor progression, and increases viability of mice suffering from cancer.
Postać fizyczna
Solution in 20 mM HEPES, pH 7.4, 300 mM NaCl, 0.01% Tween 20, 1% sucrose, 1 mM DTT.
Inne uwagi
The extracellular domain of mouse TRAIL (aa 99-291) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression.
The Journal of Experimental Medicine, 191(7), 1095-1104 (2000)
Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice.
Cancer Research, 65(5), 1687-1692 (2005)
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.
Apoptosis, 13(7), 845-856 (2008)
Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus.
Journal of Immunology, 191(11), 5515-5523 (2013)
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