SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• Synonim(y): AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: mouse
• rekombinowane: expressed in HEK 293 cells
• znacznik: FLAG^® tagged
• Próba: >90% (SDS-PAGE)
• Postać: liquid
• masa cząsteczkowa: ~22 kDa by SDS-PAGE
• opakowanie: pkg of 50 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• stężenie: ≥0.2 mg/mL
• zanieczyszczenia: <0.1 EU/μg endotoxin, tested
• kolor: clear
• numer dostępu UniProt: Q7TS55
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: mouse ... Tnfsf18(240873)

Opis

Opis ogólny

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Postać fizyczna

Solution in 10 mM glycine, pH 10.0.

Inne uwagi

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

Informacje prawne

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable