SRP6322
BMP8B human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonim(y):
BMP8, Bone morphogenetic protein 8B, OP2
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥90% (SDS-PAGE)
Postać
liquid
masa cząsteczkowa
18.1 kDa (162 aa, 264-402 aa + His tag)
opakowanie
pkg of 100 μg
stężenie
1 mg/mL
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... BMP8B(656)
Opis ogólny
The BMP8B (bone morphogenetic protein 8b) gene is mapped to human chromosome 1p34.2. It is also expressed in testis germ cell.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-β (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
Działania biochem./fizjol.
The BMP8B (bone morphogenetic protein 8b) gene expression prevents cancer cell proliferation and activates cell death. Decreased gene expression is observed in pancreatic cancer. BMP8B mediates the process of placentation, by regulating cell division, differentiation and survival. It prevents glucocorticoid-induced bone cell death.
Postać fizyczna
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle
Cao XK, et al.
Gene, 532(1), 115-120 (2013)
Developmental dysplasia of the hip: linkage mapping and whole exome sequencing identify a shared variant in CX3CR1 in all affected members of a large multigeneration family
Feldman GJ, et al.
Journal of Bone and Mineral Research, 28(12), 2540-2549 (2013)
Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
Zhao GQ and Hogan BLM
Mechanisms of Development, 57(2), 159-168 (1996)
Andrew J Whittle et al.
Cell, 149(4), 871-885 (2012-05-15)
Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced
Zhuoxin Cheng et al.
Oncology reports, 32(5), 1861-1866 (2014-09-02)
Pancreatic cancer has become one of the most common types of cancer. It is believed that inhibiting the apoptosis of tumor cells as well as overgrowth of tumor cells accelerate the progression and development of cancer. However, the detailed mechanisms
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