SRP5282

ERK1, active, GST tagged human

PRECISIO^®, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): HS44KDAP, HUMKER1A, MAPK3, MGC20180, P44ERK1, P44MAPK, PRKM3
• Numer CAS: 137632-07-6
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in E. coli
• linia produktu: PRECISIO^®
• Próba: ≥70% (SDS-PAGE)
• Postać: buffered aqueous glycerol solution
• aktywność właściwa: 672-1008 nmol/min·mg
• masa cząsteczkowa: ~72 kDa
• numer dostępu NCBI: NM_002746
• Zastosowanie: cell analysis
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... MAPK3(5595)

Opis

Opis ogólny

ERK1 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs), also known as mitogen-activated protein kinase 3 (MAPK3) which are activated in response to numerous growth factors and cytokines. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta). ERK pathway is necessary for experience-dependent plasticity and for long-term potentiation of synaptic transmission in the developing visual cortex. ERK activation affects the axonal growth by phosphorylation of microtubule-associated proteins and neurofilaments.

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informacje prawne

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable