SRP4647

Galectin-7 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonim(y): Gal-7, Galactein 7, Galectin7, HKL-14, PI7, p53-induced gene 1 protein
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in E. coli
• Próba: ≥98% (HPLC); ≥98% (SDS-PAGE)
• Formularz: lyophilized
• masa cząsteczkowa: ~15.4 kDa
• opakowanie: pkg of 50 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• zanieczyszczenia: endotoxin, tested
• numer dostępu NCBI: P47929
• numer dostępu UniProt: P47929
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... LGALS7(3963)

Opis

Opis ogólny

LGALS7 (galectin-7) is from the galectin family of β-galactoside-binding proteins. It is mainly present in the stratified epithelia, hair follicles and thymic Hassall′s corpuscles. The protein localizes in the nucleus and cytoplasm, and exists as a homodimer. Recombinant Human Galectin-7 is a 15.4kDa protein consisting of 136 amino acid residues

Działania biochem./fizjol.

LGALS7 (galectin-7) helps in maintaining skin homeostasis, particularly after skin injury. It is also involved in keratinocyte proliferation and differentiation via JNK1 (c-Jun N-terminal kinase)-miR-203-p63 pathway. LGALS7 is a biomarker for skin condition and skin barrier disruption. In HeLa cells, it induces apoptosis most likely via JNK signaling. LGALS7 is downregulated in SV40-transformed cells and squamous cell carcinoma cells. Change in its activity/expression is associated with the progression of various epithelia-associated cancers. LGALS7 also helps in postmenstrual endometrial re-epithelialization.

Postać fizyczna

Sterile filtered and Lyophilized without additives.

Rekonstytucja

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

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