SRP3266
IL-7 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonim(y):
Lymphopoietin 1 (LP-1), pre-B cell factor
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in E. coli
Próba
≥98% (HPLC)
≥98% (SDS-PAGE)
Formularz
lyophilized
siła działania
≤0.5 ng/mL ED50
masa cząsteczkowa
17.4 kDa
opakowanie
pkg of 10 μg
zanieczyszczenia
<0.1 EU/μg endotoxin, tested
kolor
white to off-white
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... IL7(3574)
Opis ogólny
IL7 (interleukin 7) was first identified in 1988 in a bone marrow culture as a factor that facilitated murine B cell precursors growth. It is a cytokine produced by non-lymphoid cells in lymphoid organs. In humans, it is also produced by keratinocytes, peripheral blood dendritic cells,follicular dendritic cells, intestinal epithelial cells, hepatic tissue, endothelial cells, smooth muscle cells and fibroblasts. IL7 gene is localized to human chromosome 8q12-q13. It is a glycoprotein with a four a-helix structure with a hydrophobic core. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.
Działania biochem./fizjol.
IL7 (interleukin 7) is crucial for lymphocyte survival and development. It is required for the survival, proliferation and the rearrangement of certain TCR (T cell receptor) genes in earliest thymus stem cells. During later stages, in thymus, it is essential for the positive selection of CD8 cells. IL7 is also essential for the survival and homeostatic proliferation of mature T cells which have left the thymus. In patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT), increased IL-7 plasma levels in the early post-transplant period is linked with suppressed T cell counts and elevated risks of acute graft-versus-host disease (aGVHD) and mortality. IL7 shows varied tear expression levels during different stages of Graves′ ophthalmopathy (GO), and thus, might be implicated in the pathogenesis of GO.
Postać fizyczna
Lyophilized from 10 mM Acetic Acid.
Rekonstytucja
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Skin Irrit. 2
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Certyfikaty analizy (CoA)
Lot/Batch Number
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Interleukin-7 expression in tears and orbital tissues of patients with Graves' ophthalmopathy.
Cai K and Wei R
Endocrine, 44, 140-144 (2013)
Cell biology of IL-7, a key lymphotrophin.
Jiang Q
Cytokine & Growth Factor Reviews, 16, 513-533 (2005)
A E Namen et al.
The Journal of experimental medicine, 167(3), 988-1002 (1988-03-01)
We have used a biological assay system we developed to biochemically purify a previously uncharacterized murine lymphopoietic growth factor designated lymphopoietin 1 (LP-1). This factor is capable of stimulating the proliferation and extended maintenance of precursor cells of the B
K Kielsen et al.
Scandinavian journal of immunology, 81(1), 72-80 (2014-09-30)
Infections and acute graft-versus-host disease (aGVHD) are major causes of treatment-related mortality and morbidity following allogeneic haematopoietic stem cell transplantation (HSCT). Both complications depend on reconstitution of the T-lymphocyte population based on donor T cells. Although it is well established
Edwin Leeansyah et al.
PLoS pathogens, 11(8), e1005072-e1005072 (2015-08-22)
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells are impaired in several chronic diseases including
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