SRP2125

RXRα, ligand binding domain, (200-462), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonim(y): FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1
• Kod UNSPSC: 12352200
• NACRES: NA.26

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in E. coli
• Próba: ≥80% (SDS-PAGE)
• Postać: frozen liquid
• masa cząsteczkowa: ~56.5 kDa
• opakowanie: pkg of 10 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• stężenie: 350 μg/mL
• kolor: clear colorless
• numer dostępu NCBI: NM_002957
• numer dostępu UniProt: P19793
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... RXRA(6256)

Opis

Działania biochem./fizjol.

Retinoid X receptor (RXR) serves as a promiscuous heterodimerization partner for many nuclear receptors through the identity box, a 40-amino acid subregion within the ligand binding domain (LBD). RXR partners include thyroid hormone receptors (TRs), retinoic acid receptors (RARs), peroxisome proliferator-activated receptor, several constitutive active orphan nuclear receptors (e.g. nuclear growth factor I-B), oxysterol receptors, and constitutive androstane receptors. RXRs also form homodimers to mediate the effects of 9-cis-retinoic acid (9-cRA). Depending on these protein-protein interactions, RXR-containing complexes have distinct ligand-dependent and constitutive functions. The LBD is functionally complex and mediates ligand binding, receptor homo- and heterodimerization, repression of transcription in the absence of ligand, and ligand-dependent activation of transcription. Hormone binding to the structurally conserved LBD of the RXR triggers a conformational change that principally affects the conserved C-terminal transactivation helix H12 involved in transcriptional activation. Coactivators directly recruited by liganded receptors include members of the steroid receptor coactivator/p160 family such as SRC-1, transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1, and RAC3/activator of thyroid and retinoic acid receptors/amplified in breast cancer 1.

Postać fizyczna

Clear and colorless frozen liquid solution

Uwaga dotycząca przygotowania

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable