SRP0283
Sphingosine kinase 1 Active human
recombinant, expressed in baculovirus, ≥80% (SDS-PAGE)
Synonim(y):
SK1, SPHK1, SPK 1
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About This Item
Kod UNSPSC:
12352204
NACRES:
NA.54
Polecane produkty
rekombinowane
expressed in baculovirus
Próba
≥80% (SDS-PAGE)
Formularz
aqueous solution
masa cząsteczkowa
46.9 kDa
numer dostępu NCBI
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... SPHK1(8877)
Opis ogólny
Human Sphingosine kinase 1 (GenBank Accession No. AF200328), full length with N-terminal His tag, MW = 46.9 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Zastosowanie
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Definicja jednostki
One unit of sphingosine kinase activity is defined as the amount of enzyme required to produce 1 pmol of S1P/min
Postać fizyczna
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol and 3 mM DTT.
Uwaga dotycząca przygotowania
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
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Journal of translational medicine, 9, 157-157 (2011-09-23)
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1α,25-Dihydroxyvitamin D3 (1,25(OH)₂D₃), a crucial regulator of calcium/phosphorus homeostasis, has important physiological effects on growth and differentiation in a variety of malignant and non-malignant cells. Synthetic structural hormone analogues, with lower hypercalcemic side effects, are currently under clinical investigation. Sphingolipids
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