SML0952

NSC23766 trihydrochloride

≥97% (HPLC)

• Synonim(y): N6-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride
• Wzór empiryczny (zapis Hilla): C₂₄H₃₅N₇ · 3HCl
• Numer CAS: 1177865-17-6
• Masa cząsteczkowa: 530.96
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Formularz: powder
• warunki przechowywania: desiccated
• kolor: white to beige
• rozpuszczalność: H₂O: 10 mg/mL, clear
• temp. przechowywania: −20°C
• ciąg SMILES: Cl.Cl.Cl.N(CCCC(Nc1nc(cc(n1)C)Nc2cc3c(nc(cc3N)C)cc2)C)(CC)CC
• InChI: 1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
• Klucz InChI: CPUHORIUXPQCHW-UHFFFAOYSA-N

Opis

Zastosowanie

NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.

Działania biochem./fizjol.

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase.

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.

Cechy i korzyści

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable