SML0760

WIKI4

≥98% (HPLC)

• Synonim(y): 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1Hbenz[de]isoquinoline-1,3(2H)-dione
• Wzór empiryczny (zapis Hilla): C₂₉H₂₃N₅O₃S
• Numer CAS: 838818-26-1
• Masa cząsteczkowa: 521.59
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 10 mg/mL, clear (warmed)
• temp. przechowywania: −20°C
• InChI: 1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3
• Klucz InChI: RNUXIZKXJOGYQP-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling with an EC₅₀ ~ 75 nM in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U2OS osteosarcoma cells, and hESCs. WIKI4 inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC₅₀ of 15 nM, preventing the ubiquitination and degradation of axin and thereby antagonizing Wnt signalling.

Cechy i korzyści

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