SMB00708

Lysobactin

≥97% (HPLC)

• Synonim(y): Katanosin B, L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone
• Wzór empiryczny (zapis Hilla): C₅₈H₉₇N₁₅O₁₇ · xC₂H₄O₂
• Numer CAS: 118374-47-3
• Masa cząsteczkowa: 1276.48 (free base basis)
• Kod UNSPSC: 41116107
• NACRES: NA.76

Właściwości

• Poziom jakości: 200
• Próba: ≥97% (HPLC)
• Postać: powder
• skład: counterion (acetate salt)
• rozpuszczalność: DMSO: 1 mg/mL
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria
• Tryb działania: cell wall synthesis | interferes
• temp. przechowywania: −20°C

Opis

Działania biochem./fizjol.

Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively).

The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability. Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable