SAE0021
Pyruvate Kinase M2 human
recombinant, expressed in E. coli, specific activity ≥100 unit/mg protein
Synonim(y):
Cytosolic Thyroid hormone-binding protein (CTHBP), M2-PK, OPA-interacting protein 3 (OIP-3), PKM2, Pyruvate kinase 3 (PK3), Pyruvate kinase muscle isozyme, p58
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About This Item
Kod UNSPSC:
12352204
NACRES:
NA.54
Polecane produkty
rekombinowane
expressed in E. coli
Poziom jakości
Postać
lyophilized powder
aktywność właściwa
≥100 units/mg protein
Warunki transportu
ambient
temp. przechowywania
−20°C
Opis ogólny
This product is recombinant human PKM2 (P14618) expressed in E. coli and has a predicted molecular mass of 58 kDa.
The embryonic pyruvate kinase M2 (PKM2) is one of the isoforms of pyruvate kinases (PK), found in mammals. It is coded by the PKM2 gene mapped to human chromosome 15q23. PKM2 is expressed in all cells excluding adult muscle, brain and liver. This protein is usually present as an active tetrameric form.
The embryonic pyruvate kinase M2 (PKM2) is one of the isoforms of pyruvate kinases (PK), found in mammals. It is coded by the PKM2 gene mapped to human chromosome 15q23. PKM2 is expressed in all cells excluding adult muscle, brain and liver. This protein is usually present as an active tetrameric form.
Zastosowanie
Human pyruvate kinase M2 (PKM2) has been used to study the effects of phosphorylated PKM2 in inactivating myofibroblasts during renal fibrosis.
Działania biochem./fizjol.
Pyruvate kinase (PK) is an important glycolytic enzyme catalyzing the last step of glycolysis, transferring a phosphate group from phosphoenolpyruvate to ADP to yield one molecule of ATP and one molecule of pyruvate.
The embryonic pyruvate kinase M2 (PKM2) controls β-catenin transactivation. It plays an important role in aerobic glycolysis or the Warburg effect. PKM2 induces gene transcription and tumorigenesis.
The embryonic pyruvate kinase M2 (PKM2) controls β-catenin transactivation. It plays an important role in aerobic glycolysis or the Warburg effect. PKM2 induces gene transcription and tumorigenesis.
Definicja jednostki
One unit will convert 1.0 μmole of phosphoenol-pyruvate to pyruvate per minute at pH 7.6 at 37 °C, in the presence of 1 mM fructose-1,6-bisphosphate.
Postać fizyczna
Supplied as a lyophilized powder containing phosphate buffer at pH7.5, NaCl, DTT and a carbohydrate stabilizer.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Klienci oglądali również te produkty
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis.
Yang W, et al.
Cell, 150(4), 685-696 (2012)
Pyruvate kinase isoenzyme M2 expression correlates with survival of cardiomyocytes after allogeneic rat heterotopic heart transplantation.
Shi J, et al.
Pathology Research and Practice, 211(1), 12-19 (2015)
Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis
Ding H, et al.
American Journal of Physiology: Renal Physiology, 313(3), F561-F575 (2017)
Gilles A Spoden et al.
Experimental cell research, 315(16), 2765-2774 (2009-07-01)
The glycolytic key regulator pyruvate kinase M2 (M2-PK or PKM2) can switch between a highly active tetrameric and an inactive dimeric form. The transition between the two conformations regulates the glycolytic flux in tumor cells. We developed specific M2-PK-binding peptide
Hao Ding et al.
American journal of physiology. Renal physiology, 313(3), F561-F575 (2017-02-24)
Chronic kidney diseases generally lead to renal fibrosis. Despite great progress having been made in identifying molecular mediators of fibrosis, the mechanism that governs renal fibrosis remains unclear, and so far no effective therapeutic antifibrosis strategy is available. Here we
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