SAB4702067

Monoclonal Anti-CD138 APC produced in mouse

• Synonim(y): SDC, SYND1, syndecan 1
• Kod UNSPSC: 12352203

Właściwości

• białko sprzężone: Allophycocyanin conjugate
• Poziom jakości: 100
• rodzaj przeciwciała: primary antibodies
• klon: MI15, monoclonal
• Postać: buffered aqueous solution
• reaktywność gatunkowa: ( Human), ( Non-human primates), rat
• metody: flow cytometry: suitable
• izotyp: IgG1κ
• numer dostępu UniProt: P18827
• temp. przechowywania: 2-8°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... SDC1(6382)

Opis

Opis ogólny

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

Specyficzność

The mouse monoclonal antibody MI15 recognizes an extracellular epitope of CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.

Immunogen

A mixture of U266 and XG-1 human myeloma cell lines

Postać fizyczna

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Uwaga dotycząca przygotowania

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Przechowywanie i stabilność

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Inne uwagi

The antibody solution should be gently mixed before use.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable