SAB4702009

Monoclonal Anti-CD73 PE produced in mouse

• Synonim(y): CALJA, E5NT, NT5E, NTE, ecto-5´nucleotidase
• Kod UNSPSC: 12352203

Właściwości

• białko sprzężone: phycoerythrin (R-PE) conjugate
• Poziom jakości: 100
• rodzaj przeciwciała: primary antibodies
• klon: AD2, monoclonal
• Formularz: buffered aqueous solution
• reaktywność gatunkowa: ( Non-human primates), human
• metody: flow cytometry: suitable
• izotyp: IgG1κ
• numer dostępu UniProt: P21589
• temp. przechowywania: 2-8°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... NT5E(4907)

Opis

Opis ogólny

CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.

Specyficzność

The mouse monoclonal antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on the surface of T and B cell subsets, follicular dendritic cells and endothelial cells.

Immunogen

pre-B leukemia cells

Postać fizyczna

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Uwaga dotycząca przygotowania

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Przechowywanie i stabilność

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Inne uwagi

The antibody solution should be gently mixed before use.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable