Przejdź do zawartości
Merck
Wszystkie zdjęcia(6)

Key Documents

SAB4503836

Sigma-Aldrich

Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit

affinity isolated antibody

Synonim(y):

Anti-IMD44, Anti-ISGF-3, Anti-P113, Anti-PTORCH3, Anti-STAT113

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych


About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen 97 kDa

reaktywność gatunkowa

human, mouse, rat

stężenie

~1 mg/mL

metody

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

phosphorylation (pTyr690)

informacje o genach

human ... STAT2(6773)

Opis ogólny

STAT2 (signal transducer and activator of transcription 2) is mapped to human chromosome 12.
Signal transducer and activator of transcription 2 (STAT2) belongs to the STAT family. The gene is located on human chromosome 12q13.3. STAT2 consists of 24 exons and has a molecular weight of 113 kDa. It consists of N-terminal domain (N), coiled-coil domain (CC), DNA-binding domain (DBD), linker domain (L), Src homology 2 domain (SH2), tyrosine phosphorylation site (Y) and transcriptional activation domain (TAD).

Immunogen

The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690.

Immunogen Range: 656-705

Zastosowanie

Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used in western blotting, immunofluorescence staining and flow cytometric staining.
Anti-phospho-STAT2 (pTyr690) antibody produced in rabbit has been used:
  • for western blotting
  • for immunofluorescence staining
  • for flow cytometric staining

Działania biochem./fizjol.

STAT2 (signal transducer and activator of transcription 2) participates in immunity. It plays a major role in interferon signaling pathways.
Signal transducer and activator of transcription 2 (STAT2) is activated by interferon-1 (IFN-I) and IFN-III. It aids protein-protein interactions and is essential for binding IRF9. STAT2 is required for the nuclear export of STAT2-IFN regulatory factor 9 (IRF9) and IFN-stimulated gene factor 3 (ISGF3). It plays a vital role in interactions with STAT1.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This page may contain text that has been machine translated.

Nie możesz znaleźć właściwego produktu?  

Wypróbuj nasz Narzędzie selektora produktów.

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
Blaszczyk K, et al.
Cytokine & Growth Factor Reviews, 29, 71-81 (2016)
Kai-Che Wei et al.
Frontiers in cellular and infection microbiology, 8, 268-268 (2018-09-07)
During the epidemic of the dengue virus (DENV) infection in Taiwan in 2014 and 2015, we observed an abnormally high frequency of increased scalp hair shedding in infected individuals that could not be explained by telogen effluvium. In this study
Fei Xing et al.
PloS one, 11(12), e0168696-e0168696 (2016-12-20)
Non-self RNA is recognized by retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), inducing type I interferons (IFNs). Type I IFN promotes the expression of IFN-stimulated genes (ISGs), which requires the activation of signal transducer and activator of transcription-1 (STAT1). We previously
Stanleyson V Hato et al.
Oncotarget, 8(33), 54434-54443 (2017-09-15)
Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal
IL-7Ralpha glutamylation and activation of transcription factor Sall3 promote group 3 ILC development
Liu B, et al.
Nature Communications, 8(1), 231-231 (2017)

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej