Przejdź do zawartości
Merck
Wszystkie zdjęcia(2)

Key Documents

Inne dokumenty

SAB4200255

Sigma-Aldrich

Anti-PP2A subunit B isoform B56-δ antibody, Mouse monoclonal

clone H5D12, purified from hybridoma cell culture

Synonim(y):

Anti-PP2A B subunit isoform PR61-δ, Anti-PP2A B subunit isoform R5-δ, Anti-PPP2R5D, Anti-Protein phosphatase 2, regulatory subunit B′,δ, Anti-Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, δ isoform

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(2)

About This Item

Kod UNSPSC:
12352203
NACRES:
NA.44

pochodzenie biologiczne

mouse

Poziom jakości

200

białko sprzężone

unconjugated

forma przeciwciała

purified from hybridoma cell culture

rodzaj przeciwciała

primary antibodies

klon

H5D12, monoclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen ~72 kDa

reaktywność gatunkowa

human, rat

stężenie

~1.0 mg/mL

metody

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS or rat Rat2 cells.

izotyp

IgG1

numer dostępu UniProt

Q14738

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... PPP2R5D(5528)

Opis ogólny

Monoclonal Anti-PP2A subunit B isoform B56-δ (mouse IgG1 isotype) is derived from the hybridoma H5D12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein. PP2A subunit B isoform B56 d (PPP2R5D) belongs to the phosphatase PP2A regulatory subunit B family. PP2A subunit B isoform B56 d (PPP2R5D) encodes a δ isoform of the regulatory subunit B56 subfamily. It is a member of phosphatase PP2A regulatory subunit B family. The core enzyme is a dimer composed of a catalytic subunit (C) and a constant regulatory subunit (A), that associates with a regulatory subunit (B).

Specyficzność

The antibody recognizes human and rat PP2A B subunit isoform B56-δ. The antibody does not cross-react with PP2A-B55, PP2A-B56-α, PP2A-B56-β, PP2A-B56-γ or PP2A-B56-ε.

Immunogen

fusion protein corresponding to the N-terminus of human PP2A B subunit isoform B56δ.

Zastosowanie

Monoclonal Anti-PP2A subunit B isoform B56-δ antibody produced in mouse has been used in immunoblotting.

Działania biochem./fizjol.

PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates cellular invasion, localization of Sgo1 at centromeres, cell movement, Ras-1 activation, and chromosome segregation. PP2A protein complex consists of a dimeric core containing subunits A and C; which in turn associates with the regulatory subunit B. PP2A subunit B is involved in the degranulation of mast cells .
Protein phosphatase 2A (PP2A) is implicated in the negative control of cell growth and division.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This page may contain text that has been machine translated.

Nie możesz znaleźć właściwego produktu?  

Wypróbuj nasz Narzędzie selektora produktów.

Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Regulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae
Jiang Y
Microbiology and Molecular Biology Reviews, 70, 440-440 (2006)
Sunanda Basu
Current protein & peptide science, 12(1), 3-11 (2010-12-31)
Cell motility is a very critical phenomenon that plays an important role in the development of eukaryotic organisms. One of the well studied cell motility phenomena is chemotaxis, which is described as a directional movement of cell in response to
Gregory Kranias et al.
Cellular signalling, 22(12), 1882-1890 (2010-08-07)
Asthma is characterised by antigen-mediated mast cell degranulation resulting in secretion of inflammatory mediators. Protein phosphatase 2A (PP2A) is a serine/threonine protein phosphatase composed of a catalytic (PP2A-C) subunit together with a core scaffold (PP2A-A) subunit and a variable, regulatory
Sean T DeGrande et al.
The Journal of biological chemistry, 288(2), 1032-1046 (2012-12-04)
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme
Zhanyun Tang et al.
Developmental cell, 10(5), 575-585 (2006-04-04)
Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and removal of cohesin from chromosome arms by mitotic kinases, including Plk1, during prophase, and (2) cleavage of centromeric cohesin by
Wyświetl wszystkie powiązane dokumenty

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej