SAB3500202

Anti-SIRPα antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonim(y): Anti-SHPS-1, Anti-SIRPa
• Numer MDL: MFCD01634182
• Kod UNSPSC: 12352203
• NACRES: NA.41
• klon: polyclonal
• application: ELISA (i); ICC; WB
• reaktywność gatunkowa: rat, mouse, human
• metody: immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• citations: 3

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: IgG fraction of antiserum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Formularz: buffered aqueous solution
• reaktywność gatunkowa: rat, mouse, human
• metody: immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• numer dostępu NCBI: NP_542970
• numer dostępu UniProt: P78324
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• informacje o genach: human ... SIRPA(140885)

Opis

Opis ogólny

Signal regulatory protein α (SIRPα) is expressed in dendritic cells and macrophages. It is a cell-surface protein. The protein possesses a highly glycosylated extracellular region, three immunoglobin superfamily domains and an intracellular domain with immunoreceptor tyrosine-based inhibitory motifs. The gene encoding SIRPα is localized on human chromosome 20p13.

Immunogen

SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.

Działania biochem./fizjol.

Signal regulatory protein α (SIRPα) acts as a modulator of immune responses. It has a role in the migration, adhesion, growth and differentiation of cells. SIRPα associates with cluster of differentiation 47 (CD47) and prevents phagocytosis by macrophages.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Powiązanie

The action of this antibody can be blocked using blocking peptide SBP3500202.

Postać fizyczna

Supplied in PBS with 0.02% sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable