Przejdź do zawartości
Merck
Wszystkie zdjęcia(2)

Kluczowe dokumenty

SAB2500845

Sigma-Aldrich

Anti-Pyruvate Carboxylase antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonim(y):

Anti-PCB

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(2)

About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

goat

Poziom jakości

100

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

reaktywność gatunkowa

mouse, human, rat, canine, pig, bovine

metody

indirect ELISA: suitable
western blot: suitable

numer dostępu UniProt

P11498

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... PC(5091)

Opis ogólny

Pyruvate carboxylase (PC), a mitochondrial enzyme, is a nuclear-encoded protein. Expression of biologically active PC is seen in skeletal muscle. PC is a homotetramer in vertebrates, with each subunit having biotin carboxylase (BC), carboxyltransferase (CT), and biotin-carboxyl carrier protein (BCCP) domains and a covalently linked biotin cofactor. The PC gene is located on human chromosome 11q13.2.

Immunogen

Peptide with sequence C-KFKEVKKAYVEANQ from the internal region of the protein sequence according to NP_000911.2; NP_001035806.1; NP_071504.2.

Zastosowanie

Anti-Pyruvate Carboxylase antibody produced in goat has been used in immunoblotting.

Działania biochem./fizjol.

Pyruvate carboxylase (PC) enzyme converts pyruvate to oxaloacetate. It plays an important role in mitochondrial metabolism in all cells and its absence is lethal. Expression of PC is highly essential for the development of pulmonary tumors. PC is involved in the pulmonary tropism of metastatic breast cancer. It is associated with the pathogenesis of ovarian cancer. Lower expression of PC can block cell proliferation, progression of the cell cycle, migration, and invasion of cells.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Nie możesz znaleźć właściwego produktu?  

Wypróbuj nasz Narzędzie selektora produktów.

Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Hongkai Shang et al.
Aging, 12(21), 21874-21889 (2020-11-13)
The aim of this study was to explore prognosis-related biomarkers and underlying mechanisms during ovarian carcinoma progression and development. mRNA expression profiles and GSE49997 dataset were downloaded. Survival analyses were performed for genes with high expression levels. Expression level of
Lisa Kappler et al.
American journal of physiology. Endocrinology and metabolism, 317(2), E374-E387 (2019-06-19)
Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial proteome and lipidome of mice and assessed the consequences
Laure Perrin-Cocon et al.
Communications biology, 4(1), 217-217 (2021-02-18)
During the cancerous transformation of normal hepatocytes into hepatocellular carcinoma (HCC), the enzyme catalyzing the first rate-limiting step of glycolysis, namely the glucokinase (GCK), is replaced by the higher affinity isoenzyme, hexokinase 2 (HK2). Here, we show that in HCC

Produkty

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej