S6949

β-Synuclein V70M histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• Synonim(y): SNCB
• Numer MDL: MFCD08705537
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in E. coli
• Poziom jakości: 200
• Próba: ≥90% (SDS-PAGE)
• Formularz: lyophilized powder
• numer dostępu UniProt: Q16143
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• informacje o genach: human ... SNCB(6620)

Opis

Działania biochem./fizjol.

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution.

Rekonstytucja

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)