P3235
Prostate Specific Antigen from human semen
buffered aqueous solution
Synonim(y):
Cancer-associated PSA, PSA
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About This Item
Polecane produkty
pochodzenie biologiczne
human semen
Poziom jakości
Próba
≥99% (SDS-GE)
Formularz
buffered aqueous solution
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... KLK3(354)
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Opis ogólny
Prostate specific antigen (PSA) is a 26kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is a highly abundant proteolytic enzyme expressed in the seminal fluid.
Działania biochem./fizjol.
Glycoprotein of the glandular kallikrein family
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.
Postać fizyczna
Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Structure, function, and regulation of the enzyme activity of prostate-specific antigen.
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Zhou AM
Clinical Chemistry, 39(12), 2483-2491 (1993)
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(2), 383-391 (2003-01-15)
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D A Armbruster
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Prostate-specific antigen (PSA) is a glycoprotein produced exclusively by prostatic tissue. PSA's absolute tissue specificity makes it valuable as a forensic marker and, more important, as a tumor marker for prostatic cancer. Prostatic cancer is prevalent in the older male
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