P0999
Anti-Potassium Channel Kv10.1 (EAG-1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonim(y):
Anti-Ether-a-go-go K+ channel 1, Anti-KCNH1
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
lyophilized powder
reaktywność gatunkowa
human, mouse, rat
metody
western blot: 1:200 using rat brain lysate and transfected cells HEK-KV10.1.
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... KCNH1(3756)
mouse ... Kcnh1(16510)
rat ... Kcnh1(65198)
Opis ogólny
Human genome codes for 40 voltage-gated K+ channels (KV). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K+ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely Kir- the inwardly rectifying 2-transmembrane K+ channels, K2P- 2-pore 4-transmembrane K+ channels, KCa- Ca2+-activated 6-transmembrane or 7-transmembrane K+ channels, and KV- voltage-gated 6-transmembrane K+ channels. KCNH1 (potassium voltage-gated channel H1) is a KV channel and is also known as KV10.1. Like all KV members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.
Specyficzność
Specific for KV10.1 and does not cross react with KV10.2.
Immunogen
peptide GDPAKRKGWARFKDAC corresponding to residues 802-817 of rat KV10.1. This sequence is identical in mouse and has 14/16 residues identical in human.
Działania biochem./fizjol.
KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K+ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.
Opis wartości docelowych
Potassium Channel Kv10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.
Postać fizyczna
Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Heike Wulff et al.
Nature reviews. Drug discovery, 8(12), 982-1001 (2009-12-02)
The human genome encodes 40 voltage-gated K(+) channels (K(V)), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca(2+) signalling and cell volume, to driving cellular proliferation and migration. K(V) channels
Voltage-gated potassium channels: from hyperexcitability to excitement.
Pongs O
Febs Letters, 452(1-2), 31-35 (1999)
Stephan Patt et al.
Neuroscience letters, 368(3), 249-253 (2004-09-15)
Ether à go-go (EAG) K(+) channels have been shown to be involved in tumor generation and malignant growth. Gliomas have not been investigated thus far. Using RT-PCR we investigated healthy human brain and human gliomas of different subtypes and malignancy
Chung-Jiuan Jeng et al.
Neuroreport, 16(3), 229-233 (2005-02-12)
Two isoforms of rat ether-a-go-go (Eag) K channels, rEag1 and rEag2, are widely expressed in many regions of the brain. The neurophysiological roles of these channels, however, are unclear. We addressed this issue by studying their subcellular localizations in hippocampal
Bo Han et al.
Scientific reports, 6, 23417-23417 (2016-03-24)
Voltage-gated ether à go-go (EAG) K(+) channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1 (hEAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and
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