O5761

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

• Wzór empiryczny (zapis Hilla): C₂₆₉H₃₈₁N₆₇O₈₂S₂
• Numer CAS: 136461-80-8
• Masa cząsteczkowa: 5929.43
• Numer MDL: MFCD03457847
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• Poziom jakości: 200
• Próba: ≥94% (HPLC)
• Postać: solid
• numer dostępu UniProt: P02818
• temp. przechowywania: −20°C
• informacje o genach: human ... BGLAP(632)

Opis

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

Opis ogólny

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.

Calcium-binding protein found in dentin and possibly other mineralized tissues.

Zastosowanie

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.

Działania biochem./fizjol.

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable