H7789

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonim(y): Anti-H1 Histone family, member 4, Anti-H1.4K26ac, Anti-H1K26ac, Anti-H1e, Anti-Histone 1, Anti-Histone H1b
• Numer MDL: MFCD09753843
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Postać: buffered aqueous solution
• masa cząsteczkowa: antigen ~35 kDa
• reaktywność gatunkowa: human
• metody: western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells
• numer dostępu UniProt: P10412
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: acetylation (Lys26)
• informacje o genach: human ... HIST1H1E(3008)

Opis

Opis ogólny

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

Immunogen

synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys²⁶) of human histone H1.4.

Zastosowanie

Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit has been used in western blotting.

Działania biochem./fizjol.

H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)