GW22779
Anti-GSK3b antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
pochodzenie biologiczne
chicken
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
reaktywność gatunkowa
mouse, human, rat
producent / nazwa handlowa
Genway 15-288-22779
metody
indirect ELISA: suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... GSK3B(2932)
Immunogen
Immunogen Sequence: GI # 21361340, sequence 21-36
Synthetic peptide sequence of glycogen synthase kinase 3β.
Zastosowanie
Anti-GSK3β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Działania biochem./fizjol.
Glycogen synthase kinase 3β is an enzyme encoded by the GSK3B gene in humans. It is closely related to protein-serine kinases and acts as an inhibitory component of Wnt signalling during embryonic development, and cell proliferation in adult tissues. GSK-3β helps in facilitating NF-κB function. It is a key endogenous factor for specifically regulating oligodendrogenesis. The genotypes may interact with major depressive disorder (MDD). GSK-3β is a proline-directed kinase that helps in forming part of the wingless signaling pathway.
Postać fizyczna
Solution in phosphate buffered saline containing 0.02% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Zhifen Liu et al.
Psychiatry research, 223(3), 210-217 (2014-07-06)
GSK3β genotypes may interact with major depressive disorder (MDD) and may have a role in determining regional gray matter volume differences from healthy comparison subjects. However, any associations of GSK3β genotypes with MDD related to abnormal functional brain activity have
Kasum Azim et al.
Glia, 62(5), 778-779 (2014-03-29)
Oligodendrocytes, the myelinating cells of the CNS, are derived postnatally from oligodendrocyte precursors (OPs) of the subventricular zone (SVZ). However, the mechanisms that regulate their generation from SVZ neural stem cells (NSC) are poorly understood. Here, we have examined the
K F Lau et al.
Genomics, 60(2), 121-128 (1999-09-16)
Glycogen synthase kinase 3beta (GSK-3beta) is a proline-directed kinase that forms part of the wingless signaling pathway. Recent studies have shown that GSK-3beta phosphorylates the microtubule-associated protein tau in vitro and in cell culture. Tau is the principal component of
Vincent F Taelman et al.
Cell, 143(7), 1136-1148 (2010-12-25)
Canonical Wnt signaling requires inhibition of Glycogen Synthase Kinase 3 (GSK3) activity, but the molecular mechanism by which this is achieved remains unclear. Here, we report that Wnt signaling triggers the sequestration of GSK3 from the cytosol into multivesicular bodies
Montserrat Romero et al.
Nature cell biology, 20(4), 443-454 (2018-03-30)
Excessive fat accumulation is a major risk factor for the development of type 2 diabetes mellitus and other common conditions, including cardiovascular disease and certain types of cancer. Here, we identify a mechanism that regulates adiposity based on the activator
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