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G1264

Sigma-Aldrich

Gentamicin sulfate salt

powder, non-animal origin, suitable for cell culture, BioReagent

Synonim(y):

Gentiomycin C

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About This Item

Numer CAS:
1405-41-0
Numer WE:
215-778-9
Numer MDL:
MFCD00270181
Kod UNSPSC:
12352207
eCl@ss:
42020823
Identyfikator substancji w PubChem:
329799833
NACRES:
NA.76

Nazwa produktu

Gentamicin sulfate salt, powder, BioReagent, suitable for cell culture

pochodzenie biologiczne

Micromonospora purpurea

Poziom jakości

200

linia produktu

BioReagent

Formularz

powder

siła działania

~600 μg Gentamicin per mg

metody

cell culture | mammalian: suitable

kolor

white to off-white

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Tryb działania

protein synthesis | interferes

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Opis ogólny

Chemical structure: aminoglycoside
Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.

Zastosowanie

Gentamicin sulfate, a broad-spectrum antibiotic, has been used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.

Działania biochem./fizjol.

Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.

Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Komponenty

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiring five equivalents of sulfuric acid per mole of gentamicin base.

Przestroga

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.

Komentarz do analizy

Solubility- freely soluble in water, practically insoluble in ethanol

Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H317

Zwroty wskazujące środki ostrożności

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Klasyfikacja zagrożeń

Skin Sens. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number
049M4874V
049M4873V
049M4872V
TEST2
019M4893V

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Odwiedź Bibliotekę dokumentów

David Gur et al.
Frontiers in microbiology, 9, 741-741 (2018-05-10)
Pneumonic plague is an infectious disease characterized by rapid and fulminant development of acute pneumonia and septicemia that results in death within days of exposure. The causative agent of pneumonic plague, Yersinia pestis (Y. pestis), is a Tier-1 bio-threat agent.
R J Collier et al.
Journal of animal science, 84 Suppl, E1-13 (2006-04-04)
Selecting domestic animals for tolerance to thermal stress (TS) has been counterproductive, because acclimation involves reducing or diverting metabolizable energy from production to balance heat gain and loss. Ideally, simultaneous selection for increased production and improved thermotolerance is desirable, but
Jianping Liu et al.
PloS one, 10(3), e0120612-e0120612 (2015-03-21)
In addition to cochleotoxicity, systemic aminoglycoside pharmacotherapy causes vestibulotoxicity resulting in imbalance and visual dysfunction. The underlying trafficking routes of systemically-administered aminoglycosides from the vasculature to the vestibular sensory hair cells are largely unknown. We investigated the trafficking of systemically-administered
Hongzhe Li et al.
PloS one, 6(4), e19130-e19130 (2011-05-10)
Exposure to intense sound or high doses of aminoglycoside antibiotics can increase hearing thresholds, induce cochlear dysfunction, disrupt hair cell morphology and promote hair cell death, leading to permanent hearing loss. When the two insults are combined, synergistic ototoxicity occurs
Meital Zilberman et al.
Acta biomaterialia, 22, 155-163 (2015-04-30)
Over the last decades, wound dressings have evolved from a crude traditional gauze dressing to tissue-engineered scaffolds. Many types of wound dressing formats are commercially available or have been investigated. We developed and studied hybrid bilayer wound dressings which combine
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