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F9911

Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

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About This Item

Kod UNSPSC:
12352202
eCl@ss:
42020141
NACRES:
NA.75

pochodzenie biologiczne

human plasma

Poziom jakości

200

Próba

>90% (SDS-PAGE)

Postać

lyophilized powder

masa cząsteczkowa

30 kDa

opakowanie

pkg of 0.5 mg

metody

cell culture | mammalian: suitable

zanieczyszczenia

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

rozpuszczalność

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

numer dostępu UniProt

P02751

Warunki transportu

ambient

temp. przechowywania

−20°C

informacje o genach

human ... FN1(2335)

Opis ogólny

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Zastosowanie

Fibronectin proteolytic fragment has been used in solid phase binding assay.

Działania biochem./fizjol.

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Przestroga

The product should be stored at -20°C.

Uwaga dotycząca przygotowania

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.
This page may contain text that has been machine translated.

Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H315,H319,H335

Zwroty wskazujące środki ostrożności

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Klasyfikacja zagrożeń

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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S Huff et al.
The Journal of biological chemistry, 269(22), 15563-15570 (1994-06-03)
The N-terminal 29-kDa fragment of fibronectin (Fn29K) contains five type I "finger" modules. It binds to heparin, fibrin, and bacteria and is involved in fibronectin (Fn) matrix assembly. Binding to Staphylococcus aureus involves a cell wall-associated protein that contains approximately
Fibronectin in Health and Disease (2018)
Maryada Sharma et al.
PloS one, 8(7), e69343-e69343 (2013-08-13)
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ. Fibronectin (Fn) is an essential component of the ECM, and plays
E Nègre et al.
The Journal of biological chemistry, 269(35), 22039-22045 (1994-09-02)
A 30-kDa proteolytic fragment from the gelatin/collagen-binding domain of fibronectin is a potent inhibitor of fibronectin binding to Candida albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin
Ming Liu et al.
Scientific reports, 5, 14449-14449 (2015-09-25)
Bacterial adhesins play a pivotal role in the tight bacteria-host cells attachment to initiate the downstream processes and bacterial infection of hosts. In this study, we identified a novel adhesin, VpadF in V. parahaemolyticus. Deletion of VpadF in V. parahaemolyticus
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Produkty

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

Protokoły

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs at sigmaaldrich.com

Protokół powlekania fibronektyną

Rozcieńczona fibronektyna do mocowania komórek, w zależności od typu komórek. Protokół powlekania, produkty i często zadawane pytania.

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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