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Merck

F135

Sigma-Aldrich

Fractalkine, Extracellular Domain human

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, suitable for cell culture, lyophilized powder

Synonim(y):

CX3CL-1, Neurotactin

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About This Item

Numer MDL:
Kod UNSPSC:
51111800
NACRES:
NA.32

pochodzenie biologiczne

human

Poziom jakości

rekombinowane

expressed in NSO cells

Próba

≥97% (SDS-PAGE)

Formularz

lyophilized powder

siła działania

22.62 ng/mL

masa cząsteczkowa

~90 kDa

opakowanie

pkg of 25 μg

warunki przechowywania

avoid repeated freeze/thaw cycles

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, tested

numer dostępu UniProt

temp. przechowywania

−20°C

informacje o genach

human ... CX3CL1(6376)

Opis ogólny

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.

Działania biochem./fizjol.

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.

Postać fizyczna

Lyophilized from a 0.2 μm-filtered solution in PBS containing 50 μg bovine serum albumin per 1 μg of cytokine

Komentarz do analizy

Biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes or mouse BaF/3 cells transfected with hCX3CR-1.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Jian Wang et al.
Molecular medicine reports, 24(6) (2021-10-06)
Angina pectoris is cardiac pain that is a common clinical symptom often resulting from myocardial ischemia. Spinal cord stimulation (SCS) is effective in treating refractory angina pectoris, but its underlying mechanisms have not been fully elucidated. The spinal dorsal horn
Gemma E White et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(12), 2554-2562 (2014-11-02)
The CX3C chemokine fractalkine (CX3CL1) has a critical role in the development of atherogenesis because apolipoprotein-E-deficient mice lacking CX3CL1 or its receptor CX3CR1 develop smaller plaques and polymorphisms in CX3CR1 are associated with altered risk of cardiovascular disease. CX3CR1 is
Selma Unal et al.
International journal of hematology, 101(2), 114-118 (2014-12-07)
In the present study, we examined the role of fractalkine (Fkn), a member of the chemokine family, in the pathogenesis of sickle cell disease (SCD). Eighty-seven children with sickle cell disease and 55 healthy children were enrolled in the study.

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