D3254

7,12-Dimethylbenz[a]anthracene

≥95%

• Synonim(y): 1,4-Dimethyl-2,3-benzophenanthrene, 9,10-Dimethyl-1,2-benzanthracene, DMBA
• Wzór empiryczny (zapis Hilla): C₂₀H₁₆
• Numer CAS: 57-97-6
• Masa cząsteczkowa: 256.34
• Beilstein: 1912135
• Numer WE: 200-359-5
• Numer MDL: MFCD00003600
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24893738
• NACRES: NA.25

Właściwości

• Poziom jakości: 200
• Próba: ≥95%
• Formularz: powder
• mp: 122-123 °C (lit.)
• Zastosowanie: metabolomics; vitamins, nutraceuticals, and natural products
• ciąg SMILES: Cc1c2ccccc2c(C)c3c1ccc4ccccc34
• InChI: 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
• Klucz InChI: ARSRBNBHOADGJU-UHFFFAOYSA-N

Opis

Opis ogólny

7,12-Dimethylbenz[a]anthracene belongs to the category of polycyclic aromatic hydrocarbons. It is a carcinogenic organic pollutant generated from the incomplete combustion of gasoline and coal.

Zastosowanie

7,12-Dimethylbenz[a]anthracene was used:

• to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
• in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
• to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12^doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
• to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen

Działania biochem./fizjol.

7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H350
• Zwroty wskazujące środki ostrożności: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Carc. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges