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Merck

C9473

Sigma-Aldrich

Complement Serum Standard human

aqueous solution

Synonim(y):

Human Complement Serum

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About This Item

Kod UNSPSC:
12352202
NACRES:
NA.61

pochodzenie biologiczne

human

Poziom jakości

Postać

aqueous solution

Zastosowanie

cell analysis

Warunki transportu

dry ice

temp. przechowywania

−70°C

Opis ogólny

The complement serum standard human is suitable for the determination of CH50 and AP50 complement activities. This allows for a test of the complement activity on the capacity of the serum to lyse red blood cells in vitro and can be used in procedures for genotyping DNA samples of the complement system.

Zastosowanie

Complement Serum Standard human has been used as a positive control to study the role of the complement system in immunological demyelination of the spinal cord from mammals.

Działania biochem./fizjol.

The complement system is an important constituent of innate immunity. It participates in the first line of defense against microbial infections, altered host cells, and removal of immune complexes and injured cells. The complement system comprises more than thirty components such as the plasma proteins produced by the liver, membrane proteins expressed on the cell surface, cytokines, and hormones. The complement proteins come together to opsonize the pathogens and initiate a cascade of inflammatory responses serving the immune cells to fight the infection and maintain homeostasis.

Postać fizyczna

Supplied as a 0.22 μm filtered solution containing ~ 18 mM citrate, ~22 mM dextrose, ~3 mM phosphate and ~13 mM calcium

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

J K Dyer et al.
Spinal cord, 43(7), 417-425 (2005-05-18)
Specificity of serum complement component to elicit immunological demyelination. To assess the role of complement components and pathways in experimental immunological demyelination of the adult rat spinal cord. ICORD, University of British Columbia, Vancouver, Canada. We used 32 adult male
Risk Alleles in CFH and ARMS2 Are Independently Associated with Systemic Complement Activation in Age-related Macular Degeneration.
Smailhodzic D., et al.
Ophthalmology (2011)
P J Francis et al.
Journal of medical genetics, 46(5), 300-307 (2008-11-19)
Age related macular degeneration (AMD) is a leading cause of blindness. AMD is a complex disorder caused by genetic and environmental factors in which single nucleotide polymorphisms (SNPs) in the genes CFH and LOC387715/HTRA1/ARMS2 have prognostic importance for progression to
Jordan E Inglis et al.
Advances in physiology education, 32(4), 317-321 (2008-12-03)
The immune system is a vital physiological component that affords animals protection from disease and is composed of innate and adaptive mechanisms that rely on cellular and dissolved components. The serum complement system is a series of dissolved proteins that

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