C8655

4-Chloro-L-phenylalanine

• Synonim(y): L-PCPA
• Wzór liniowy: ClC₆H₄CH₂CH(NH₂)CO₂H
• Numer CAS: 14173-39-8
• Masa cząsteczkowa: 199.63
• Beilstein: 2416150
• Numer WE: 238-023-5
• Numer MDL: MFCD00063065
• Kod UNSPSC: 12352209
• eCl@ss: 32160406
• Identyfikator substancji w PubChem: 24893091
• NACRES: NA.32

Właściwości

• Postać: powder
• mp: 263 °C (dec.) (lit.)
• temp. przechowywania: −20°C
• ciąg SMILES: N[C@@H](Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
• Klucz InChI: NIGWMJHCCYYCSF-QMMMGPOBSA-N
• informacje o genach: human ... TPH1(7166) , TPH2(121278) ; mouse ... TPH1(21990) , TPH2(216343) ; rat ... TPH1(24848) , TPH2(317675)

Opis

Zastosowanie

4-Chloro-L-phenylalanine (L-PCPA) has been used:

• to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
• to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio)
• as a substrate for Chromobacterium violaceum phenylalanine hydroxylase
• to incubate sea urchin embryos for immunohistochemistry

Działania biochem./fizjol.

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.

Tryptophan hydroxylase inhibitor.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges