C4483
CD152/Fc Chimera, Cytolytic from mouse
recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonim(y):
CTLA4/Fc Chimera, cytolytic
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About This Item
pochodzenie biologiczne
mouse
Poziom jakości
rekombinowane
expressed in NS.1 cells
Próba
≥99% (SDS-PAGE)
Formularz
buffered aqueous solution
masa cząsteczkowa
97 kDa
opakowanie
pkg of 1 mg
warunki przechowywania
avoid repeated freeze/thaw cycles
zanieczyszczenia
≤1 EU/mg protein Endotoxin level (LAL test)
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
mouse ... Cd152(12477) , Ctla4(12477)
Opis ogólny
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Działania biochem./fizjol.
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
Inne uwagi
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
Postać fizyczna
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
Uwaga dotycząca przygotowania
Purified from serum-free tissue culture supernatant
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate interleukin 2 production
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