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Key Documents

C1743

Sigma-Aldrich

Anti-Cul7 antibody, Mouse monoclonal

clone Ab38, purified from hybridoma cell culture

Synonim(y):

Anti-Cullin 7, Anti-KIAA007

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About This Item

Numer MDL:
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

białko sprzężone

unconjugated

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

Ab38, monoclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen ~180 kDa

reaktywność gatunkowa

human, mouse

stężenie

~2 mg/mL

metody

immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using 3T3 total cel extract

izotyp

IgG2b

numer dostępu UniProt

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... CUL7(9820)
mouse ... Cul7(66515)

Opis ogólny

Monoclonal Anti-Cul7 (mouse IgG2b isotype) is derived from the hybridoma Ab38 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from BALB/c mice immunized with mouse Cul7. CUL7 is expressed in all tissues and cell lines except testis and small intestine.

Immunogen

mouse Cul7.

Zastosowanie

Monoclonal Anti-Cul7 antibody produced in mouse is suitable for immunoprecipitation and western blotting at a concentration of 0.5-1μg/mL using 3T3 total cel extract.

Działania biochem./fizjol.

CUL7 functions to promote cell growth through and antagonizes the function of p53.
Cullin-7 (cul7) is a protein encoded by the CUL7 gene in humans. It is also referred as 3M1, KIAA0076 and dJ20C7.5. Mutation in CUL7 gene is majorly responsible for 3M syndrome (is a rare autosomal recessive disorder). CUL7 acts as a novel gene potentially involved in liver carcinogenesis associated with metabolic syndrome (MS) and its amplification may influence cell proliferation.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Cristina Meazza et al.
Italian journal of pediatrics, 39, 21-21 (2013-03-23)
3-M syndrome is a rare autosomal recessive disorder that causes short stature, unusual facial features and skeletal abnormalities. Mutations in the CUL7, OBSL1 and CCDC8 genes could be responsible for 3-M syndrome.Here we describe the growth and evolution of dismorphic
Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function
Andrews P, et al.
Oncogene, 25(33), 4534-4534 (2006)
Céline Huber et al.
Best practice & research. Clinical endocrinology & metabolism, 25(1), 143-151 (2011-03-15)
3M syndrome (MIM 273750) is an autosomal recessive disorder characterized by pre- and post-natal growth retardation (<-4 SD), facial dysmorphism, large head circumference, normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. There
Céline Huber et al.
European journal of human genetics : EJHG, 17(3), 395-400 (2009-02-20)
The 3M syndrome is a rare autosomal recessive disorder recently ascribed to mutations in the CUL7 gene and characterized by severe pre- and postnatal growth retardation. Studying a series of 33 novel cases of 3M syndrome, we have identified deleterious
Valerie Paradis et al.
Gut, 62(6), 911-919 (2012-09-04)
Metabolic syndrome (MS) is an emerging risk factor in hepatocellular carcinoma (HCC). HCC related to MS may occur either in advanced fibrosis or before the development of cirrhosis, suggesting involvement of different molecular pathways according to the features of background

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