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C1649
Cardiolipin solution from bovine heart
4.7-5.3 mg/mL in ethanol, ≥97% (TLC)
Synonim(y):
Roztwór difosfatydyloglicerolu
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About This Item
Polecane produkty
pochodzenie biologiczne
bovine heart
Poziom jakości
Próba
≥97% (TLC)
Formularz
liquid
opakowanie
glass bottle of
stężenie
4.7-5.3 mg/mL in ethanol
kolor
colorless to yellow
Zastosowanie
general analytical
lipidomics
metabolomics
grupa funkcyjna
phospholipid
typ lipidu
phosphoglycerides
Warunki transportu
dry ice
temp. przechowywania
−20°C
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Opis ogólny
Cardiolipin (CL) is a complex lipid with a dimeric structure. It has four acyl chains and two phosphatidyl moieties. Its phosphatidyl moieties are linked to the glycerol backbone. Around 15-20 percent of the inner mitochondrial membrane accounts for cardiolipin.
Cardiolipin is a unique phospholipid found exclusively within the mitochondrial inner membrane. This specific localization allows Cardiolipin to exert crucial influence on mitochondrial structure and function. Deviations in Cardiolipin content, structure, or localization can lead to impaired mitochondrial activity, contributing to various diseases like cancer, neurological disorders, cardiovascular conditions, and metabolic diseases. As Cardiolipin plays a crucial role in mitochondrial function, it holds immense potential for biomarker development and finds application in cardiovascular, neuroscience, cancer, diabetes, and metabolomics research.
Zastosowanie
Cardiolipin solution from bovine heart has been used:
- for coating Corning 96-well enzyme immunoassay/radioimmunoassay (EIA/RIA) plate to perform enzyme-linked immunosorbent assay (ELISA)-based cardiolipin binding assay
- in lipid analysis along with phosphatidylglycerol (PG) to comigrate the radiolabeled lipids to identify PG and cardiolipin (CL)
- in coating ELISA plates for antiphospholipid antibodies (aPL) assays
Działania biochem./fizjol.
Cardiolipin (CL) plays a key role in mitochondrial biogenesis, fusion and fission, respiration, and protein import. It participates in the cellular processes outside of the mitochondria like cell wall biogenesis, aging, vacuole homeostasis, the cell cycle, and apoptosis. CL is also involved in heart function, autophagy/mitophagy, and the protein kinase C (PKC) pathway.
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component and can inhibit cell attachment of fibronectin, vitronectin, and type I collagen.
Cechy i korzyści
- High-quality molecule suitable for mulitple research applications
- Commonly employed in Metabolomics and Biochemical studies
Inne uwagi
>80% polyunsaturated fatty acid content, primarily linoleic acid.
For additional information on our range of Biochemicals, please complete this form.
Postać fizyczna
Approximately 5 mg/ml in ethanol.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Flam. Liq. 2
Kod klasy składowania
3 - Flammable liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
55.4 °F - closed cup
Temperatura zapłonu (°C)
13 °C - closed cup
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Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
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