B5050
Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse
clone 35928.11, purified immunoglobulin, lyophilized powder
Synonim(y):
Anti-BDNF
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
35928.11, monoclonal
Formularz
lyophilized powder
reaktywność gatunkowa
human
metody
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-25 μg/mL using human spinal cord
western blot: 1-2 μg/mL
izotyp
IgG1
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... BDNF(627)
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Opis ogólny
The antibody shows ~5% cross-reactivity with recombinant human β−NGF and recombinant rat β−NGF.
Immunogen
Recombinant human BDNF, expressed in Sf 21 cells.
Zastosowanie
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Działania biochem./fizjol.
Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Uwaga dotycząca przygotowania
Purified from ascites fluid using protein A.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
produkt powiązany
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Kunlin Jin et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18189-18194 (2005-12-06)
There is no satisfactory treatment for Huntington's disease (HD), a hereditary neurodegenerative disorder that produces chorea, dementia, and death. One potential treatment strategy involves the replacement of dead neurons by stimulating the proliferation of endogenous neuronal precursors (neurogenesis) and their
Gabriele Baj et al.
Journal of cell science, 129(14), 2852-2864 (2016-06-09)
Brain-derived neurotrophic factor (BDNF) is encoded by multiple mRNA variants whose differential subcellular distribution constitutes a 'spatial code' for local translation of BDNF and selective morphological remodeling of dendrites. Here, we investigated where BDNF translation takes place and what are
Risa Takahara-Yamauchi et al.
Biomedical research (Tokyo, Japan), 42(2), 67-76 (2021-04-13)
In this study, we employed a rodent model for persistent allodynia and hyperalgesia to determine whether voluntary exercise could exert analgesic effects on these pain symptoms. Rats were subcutaneously injected with formalin into the plantar surface of the right hind
Joanne L Jones et al.
Brain : a journal of neurology, 133(Pt 8), 2232-2247 (2010-07-28)
Treatment of early relapsing-remitting multiple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [registered trade mark]) significantly reduced the risk of relapse and accumulation of disability compared with interferon β-1a in a phase 2 trial [Coles et al., (Alemtuzumab
Tsuyoshi Inagaki et al.
Neuroscience research, 61(2), 192-200 (2008-04-09)
High-frequency stimulation (HFS) induces long-term potentiation (LTP) at inhibitory synapses of layer 5 pyramidal neurons in developing rat visual cortex. This LTP requires postsynaptic Ca2+ rise for induction, while the maintenance mechanism is present at the presynaptic site, suggesting presynaptic
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