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Key Documents

ABK0016

Sigma-Aldrich

UsteBridge ELISA Kit from rabbit serum

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About This Item

Kod UNSPSC:
41116158
NACRES:
NA.32

forma przeciwciała

purified immunoglobulin

reaktywność gatunkowa

human (IgG)

Warunki transportu

wet ice

temp. przechowywania

2-8°C

Opis ogólny

A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of Ustekinumab. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded Ustekinumab. For a Stelara Biosimilar, if the protein is correctly folded and glycosylated, the ‘fingerprint′ will match that of Ustekinumab. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ‘fingerprint′ generated by the ELISA will point out differences between the Biosimilar and authentic Ustekinumab.

Zastosowanie

For research use only. Not for use in diagnostic procedures.

Inne uwagi

ELISA kit contains 3 96-well microplates and all the components necessary to complete an ELISA test.
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Piktogramy

Corrosion
GHS05

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H290,H315,H319

Klasyfikacja zagrożeń

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Kod klasy składowania

8A - Combustible corrosive hazardous materials

Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Xing Wang et al.
Frontiers in pharmacology, 4, 103-103 (2013-08-24)
Antibody arrays were developed to probe a monoclonal antibody's three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain, respectively, and used to generate polyclonal antibodies after the conjugation of
Yuanli Song et al.
mAbs, 10(3), 397-405 (2018-01-10)
The elucidation of antibody higher order structure (HOS) is critical in therapeutic antibody development. Since HOS determines the protein bioactivity and chemo-physical properties, this knowledge can help to ensure that the safety and efficacy attributes are not compromised. Protein conformational
Biosimilar mAb in-process Sample Higher Order Structure Analysis with Protein Conformational Array ELISA.
Michael Davies, Gan Wang, Jian Gong, Guofeng Fu and Xing Wang
Pharmaceut. Res., 1-11 (2016)
Soon Kwan Jung et al.
mAbs, 6(5), 1163-1177 (2014-12-18)
Remsima (infliximab) was recently approved as the world's first biosimilar monoclonal antibody (mAb) in both the European Union and Korea. To achieve this, extensive physicochemical characterization of Remsima in relation to Remicade was conducted in order to demonstrate the highly

Produkty

Protein Conformation Array Multiplexing

Monoclonal antibodies (mAbs) are the fastest growing class of human therapeutics within the field of biologics, having predicted worldwide sales of $125 billion by 2020 based on current approval rates.

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