A4559

Amyloid β-Protein Fragment 25-35

≥97% (HPLC)

• Wzór empiryczny (zapis Hilla): C₄₅H₈₁N₁₃O₁₄S
• Numer CAS: 131602-53-4
• Masa cząsteczkowa: 1060.27
• Numer MDL: MFCD00133076
• Kod UNSPSC: 12352202
• Identyfikator substancji w PubChem: 24890880
• NACRES: NA.32

Właściwości

• Poziom jakości: 200
• Próba: ≥97% (HPLC)
• Formularz: powder
• skład: Protein Content, ≥80%
• numer dostępu UniProt: P05067
• temp. przechowywania: −20°C
• ciąg SMILES: CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)
• Klucz InChI: WIHBNMPFWRHGDF-UHFFFAOYSA-N
• informacje o genach: human ... APP(351)

Opis

Amino Acid Sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Opis ogólny

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1−40) peptides. It has a β-sheet and β-turn structure.

Zastosowanie

Amyloid β-Protein Fragment 25-35 has been used:

• to induce neurotoxicity in cortical cultures
• to induce Alzheimer′s disease in rat model
• to induce apoptosis in mesenchymal stem cells (MSCs)

Działania biochem./fizjol.

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Inne uwagi

Lyophilized from 0.1% TFA in H2O

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)