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Phalloidin–Atto 425
suitable for fluorescence, ≥90% (HPLC)
Synonim(y):
Atto 425–Phalloidin
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About This Item
Kod UNSPSC:
12352116
NACRES:
NA.32
Polecane produkty
Poziom jakości
Próba
≥90% (HPLC)
producent / nazwa handlowa
ATTO-TEC GmbH
λ
in methanol
absorpcja UV
λ: 429-435 nm Amax
przydatność
suitable for fluorescence
temp. przechowywania
−20°C
Opis ogólny
Atto 425 Phalloidin is a novel fluorescent label with a coumarin structure. The dye is intended for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are strong absorption, high fluorescence quantum yield, large Stokes-shift, good photostability, and low molecular weight.Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10–8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours.
Zastosowanie
Fluorescent conjugates of phalloidin, rhodamine-phalloidin staining reagents, such as Phalloidin–Atto 425 are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.
Informacje prawne
This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Produkty
Barwniki Atto to seria barwników fluorescencyjnych, które spełniają krytyczne potrzeby nowoczesnych technologii fluorescencyjnych.
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