T2005010
Triflusal impurity B
European Pharmacopoeia (EP) Reference Standard
Synonim(y):
2-Hydroxy-4-(trifluoromethyl)benzoic acid, 4-(Trifluoromethyl)salicylic acid
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About This Item
Wzór empiryczny (zapis Hilla):
C8H5F3O3
Numer CAS:
Masa cząsteczkowa:
206.12
Kod UNSPSC:
41116107
NACRES:
NA.24
Polecane produkty
klasa czystości
pharmaceutical primary standard
rodzina API
triflusal
producent / nazwa handlowa
EDQM
Zastosowanie
pharmaceutical (small molecule)
Format
neat
temp. przechowywania
2-8°C
ciąg SMILES
FC(F)(F)c1cc(c(cc1)C(=O)O)O
InChI
1S/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14)
Klucz InChI
XMLFPUBZFSJWCN-UHFFFAOYSA-N
Opis ogólny
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Zastosowanie
Triflusal impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Opakowanie
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Inne uwagi
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Anna Argemí et al.
Journal of pharmaceutical and biomedical analysis, 46(3), 456-462 (2007-12-21)
This study describes the development and evaluation of an analytical method for the characterization of triflusal (2-acetoxy-4-(trifluoromethyl) benzoic acid) dispersed in sustained delivery systems prepared using supercritical fluid impregnation technology. Characterization assays comprised the determination of the percentage of triflusal
J A González-Correa et al.
Naunyn-Schmiedeberg's archives of pharmacology, 371(1), 81-88 (2004-12-17)
Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity. Recently, evidence for a neuroprotective effect has been obtained. The aim of this study was to compare the neuroprotective effects of the main metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic
J García-Rafanell et al.
Archives internationales de pharmacodynamie et de therapie, 284(1), 155-165 (1986-11-01)
The effect of triflusal, acetylsalicylic acid (ASA), and of their principal metabolites 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) and salicylic acid (SA), alone or combined with dypiridamole (DIP) and/or PGE1 on cyclic AMP levels in washed rat platelets (37 degrees C, 4 min)
R Mis et al.
The Journal of pharmacy and pharmacology, 44(11), 935-937 (1992-11-01)
2-Hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of triflusal, an antiplatelet drug. The in-vitro binding of HTB to human serum was studied in the presence of different drugs. The results indicate that no statistically significant changes are observed in
J Ramis et al.
European journal of drug metabolism and pharmacokinetics, 16(4), 269-273 (1991-10-01)
The pharmacokinetic profile of triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) and its main metabolite HTB (2-hydroxy-4-trifluoromethyl benzoic acid) has been studied in 8 healthy subjects (4 males and 4 females), after a single oral dose of 900 mg of triflusal. Plasma concentrations
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