MABN748

Anti-TrpC3, clone 10H6 Antibody

clone 10H6, from mouse

• Synonim(y): Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: 10H6, monoclonal
• reaktywność gatunkowa: mouse
• reaktywność gatunkowa (przewidywana na podstawie homologii): human (based on 100% sequence homology)
• metody: western blot: suitable
• izotyp: IgG1
• numer dostępu NCBI: NP_001124170
• numer dostępu UniProt: Q13507
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... TRPC3(7222)

Opis

Opis ogólny

TrpC3, also known as Short transient receptor potential channel 3, transient receptor protein 3 or TRP-3, and encoded by the gene TRPC3/TRP3, forms a receptor activated calcium channel that is activated via ligand binding and transduces signals via the G-protein coupled tyrosine receptor kinases pathways.TrpC3 can also be activated by the release of internal calcium and is one of the principal receptors involved in maintaining Ca++ ion homeostasis in skeletal muscles and nervous tissue. TrpC3 is also a principal receptor involved in the Capacitative calcium entry (CCE) which is the mechanism behind Ca++ influx into cells that replenishes internal calcium stores. Additionally, TrpC3 receptor is important in axon guidance, phototransduction, and platelet activation. TrpC3 is localized to the cell membrane and consists of a multipass-though transport protein. TrpC3 is expressed principally in the brain but is also found in most other tissues and organs at lowered levels.

Immunogen

Recombinant protein corresponding to mouse TrpC3.

Zastosowanie

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-TrpC3, clone 10H6 Antibody is validated for use in Western Blotting for the detection of TrpC3.

Western Blotting Analysis: A representative lot detected TrpC3 in cerebellar tissues of TRPC3 wild type mice and not TRPC3 knock out mice (Prof. Yizheng Wang, Shanghai Institutes for Biological Sciences (SIBS).
Western Blotting Analysis: A representative lot detected TrpC3 in rat liver and brain tissue lysates (Feng. S., et al. (2013). PNAS. 1-6).

Jakość

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TrpC3 in 10 µg of mouse brain tissue lysate.

Opis wartości docelowych

~110 kDa observed.

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable