MABN642

Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody

clone 1H10.1, from mouse

• Synonim(y): Glutathione S-transferase omega-1, GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, S-(Phenacyl)glutathione reductase, SPG-R, GST Omega 1 (GSTO1)
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• rodzaj przeciwciała: primary antibodies
• klon: 1H10.1, monoclonal
• reaktywność gatunkowa: rat, human
• metody: immunohistochemistry: suitable (paraffin); western blot: suitable
• izotyp: IgG1κ
• numer dostępu NCBI: NP_001177931
• numer dostępu UniProt: P78417
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... GSTO1(9446)

Opis

Opis ogólny

GST Omega 1 (GSTO1), also known as Glutathione S-transferase omega-1,GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V), or S-(Phenacyl)glutathione reductase, SPG-R, and encoded by the gene GSTO1/GSTTLP28, a ubiquitously expressed cytoplasmic enzyme that is highest in the liver and lowest in the brain It belongs to the GST superfamily of anti-oxidant reducing enzymes and is in the omega class. The omega class of glutathione transferases (GSTs) is a relatively ancient member of the cytosolic GST superfamily, and the omega-class GSTs are found in plants, animals, and some microbial species. The omega-class, unlike other GSTs, has a cysteine residue in their active site. Consequently, the omega-class GSTs catalyze a range of thiol transferase and reduction reactions that are not catalyzed by members of the other classes. GST Omega 1 (GSTO1) is involved in L-ascorbic acid metabolism, detoxification of arsenic substances, glutathione biosynthetic processes, regulation of ryanodine-sensitive calcium release channels, regulation of skeletal muscle contraction and the release of sequestered calcium in muscle, and xenobiotic catabolism. Interestingly genetic linkage studies have discovered associations between GSTO1 gene mutations and the age at onset of Alzheimer′s disease, Parkinson′s disease, and amyotrophic lateral sclerosis, perhaps stemming from the capacity of omega-class GSTs to mitigate oxidative stress or their role in activating the proinflammatory cytokine, interleukin-1β.

Immunogen

GST-tagged recombinant protein corresponding to human GST Omega 1 (GSTO1).

Zastosowanie

Immunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected GST Omega 1 (GSTO1) in human cerebral cortex and rat cerebellum tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GST Omega 1 (GSTO1).

Jakość

Evaluated by Western Blotting in human heart tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected GST Omega 1 (GSTO1) in 200 µg of human heart tissue lysate.

Opis wartości docelowych

~28 kDa observed

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable